Pyrrolidine → HCID 22632990, compound

HRID 2270232Notes

Reaction equation

HRID 2270232 reaction equation
[CH2:1]([N:8]1[C:13]2[N:14]=[C:15](Cl)[C:16]([F:18])=[CH:17][C:12]=2[C:11](=[O:20])[N:10]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:9]1=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1>ClCCl>[CH2:1]([N:8]1[C:13]2[N:14]=[C:15]([N:30]3[CH2:34][CH2:33][CH2:32][CH2:31]3)[C:16]([F:18])=[CH:17][C:12]=2[C:11](=[O:20])[N:10]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:9]1=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 22633017HCID 22633017, compound

Product 1

HCID 22632990HCID 22632990, compoundYield 78.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the procedure of Example X-2, the reaction of 1-benzyl-3-benzyloxy-7-chloro-6-fluoro-1H-pyrido[2,3-d]pyrimidine-2,4-dione (Example P-2, 142 mg, 0.345 mmol) with pyrrolidine (0.070 mL, 0.828 mmol) in dichloromethane (3 mL) afforded 121 mg of the title compound as a solid, mp 171-172° C.

Sources & evidence

ORD record
ord-644343ba6127487f982a703bf493052d
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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