反应详情

Prepared from 402 mg (1.0 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 3 mL THF and 513 mg (2.2 mmol) of 5-iodo-2,3-dimethyl-pyridine in 5 mL THF with 1.15 mL 2M isopropylmagnesium chloride. Yield: 296 mg of a white powder. LC-MSD, m/z for C23H18BrN3O2 [M+H]+=448.0, 450.0; HPLC retention time: 1.9 min.