HCID 22632871, compound → HCID 22632891, compound

HRID 2270274Notes

Reaction equation

HRID 2270274 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:31])=[C:15]([N:18]4[CH2:22][CH2:21][CH:20]([NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:19]4)[CH:16]=3)[C:11](=[O:32])[N:10]([O:33]CC3C=CC=CC=3)[C:9]2=[O:41])=[CH:4][CH:3]=1>[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:31])=[C:15]([N:18]4[CH2:22][CH2:21][CH:20]([NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:19]4)[CH:16]=3)[C:11](=[O:32])[N:10]([OH:33])[C:9]2=[O:41])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 22632871HCID 22632871, compound

Product 1

HCID 22632891HCID 22632891, compoundYield 95.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using the General Method 6A, the reaction of 10% Pd/C (0.075 g) with 1-(4-fluorophenyl)-6-fluoro-3-benzyloxy-7-(3-t-butoxycarbonylamino-pyrrolidin-1-yl)-1H-quinazoline-2,4-dione (Example N-1, 0.225 g, 0.4 mmol) afforded 0.182 g of 1-(4-fluorophenyl)-6fluoro-3-hydroxy-7-(3-t-butoxycarbonylamino-pyrrolidin-1-yl)-1H-quinazoline-2,4-dione.

Sources & evidence

ORD record
ord-d393891ecf2c4b2e846d998c2f4d8fd3
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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