HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 22632871, compound → HCID 22632891, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 22632871 | HCID 22632871 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | HCID 22632891 | HCID 22632891 | 95.9% |
Reaction Steps
Using the General Method 6A, the reaction of 10% Pd/C (0.075 g) with 1-(4-fluorophenyl)-6-fluoro-3-benzyloxy-7-(3-t-butoxycarbonylamino-pyrrolidin-1-yl)-1H-quinazoline-2,4-dione (Example N-1, 0.225 g, 0.4 mmol) afforded 0.182 g of 1-(4-fluorophenyl)-6fluoro-3-hydroxy-7-(3-t-butoxycarbonylamino-pyrrolidin-1-yl)-1H-quinazoline-2,4-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06331538B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-d393891ecf2c4b2e846d998c2f4d8fd3 |
| Source note | uspto-grants-2001_12 |