HCID 22632963, compound → HCID 22633000, compound

HRID 2270280Notes

Reaction equation

HRID 2270280 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:26])=[C:16]([N:19]4[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]4)[CH:17]=3)[C:12](=[O:27])[N:11]([O:28]CC3C=CC=CC=3)[C:10]2=[O:36])[CH:6]=[CH:7][CH:8]=1>[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:26])=[C:16]([N:19]4[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]4)[CH:17]=3)[C:12](=[O:27])[N:11]([OH:28])[C:10]2=[O:36])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 22632963HCID 22632963, compound

Product 1

HCID 22633000HCID 22633000, compoundYield 83.2%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using the General Method 6A, the reaction of 10% Pd/C (0.04 g) with 1-(3-methoxyphenyl)-6-fluoro-3-benzyloxy-7-(4-methylpiperazin-1-yl)-1H-quinazoline-2,4-dione (Example U-1, 0.12 g, 0.24 mmol) afforded 0.08 g of the title compound as a solid, mp 158-160° C.

Sources & evidence

ORD record
ord-90c58944b79c452fb565ec4b1e872ebe
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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