HCID 22633026, compound → HCID 22632949, compound

HRID 2270282Notes

Reaction equation

HRID 2270282 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:23])=[C:15]([N:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)[CH:16]=2)[C:11](=[O:24])[N:10]([O:25]CC2C=CC=CC=2)[C:9]1=[O:33]>[Pd]>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:23])=[C:15]([N:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)[CH:16]=2)[C:11](=[O:24])[N:10]([OH:25])[C:9]1=[O:33]

Participants

3

Reactant 1

HCID 22633026HCID 22633026, compound

Product 1

HCID 22632949HCID 22632949, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using the General Method 6A, the reaction of 10% Pd/C (0.03 g) with 1-(2-fluorophenyl)-6-fluoro-3-benzyloxy-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione (Example W-1, 0g, 0.22 mmol) provided 0.07 g of the title compound as a solid, mp 235-237° C.

Sources & evidence

ORD record
ord-f53a402c298e443286fead5aa8ac5d29
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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