HCID 22632900, compound → HCID 22632928, compound

HRID 2270285Notes

Reaction equation

HRID 2270285 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:25])=[C:15]([N:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)[CH:16]=3)[C:11](=[O:26])[N:10]([O:27]CC3C=CC=CC=3)[C:9]2=[O:35])[CH:5]=[CH:6][CH:7]=1>[Pd]>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:25])=[C:15]([N:18]4[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]4)[CH:16]=3)[C:11](=[O:26])[N:10]([OH:27])[C:9]2=[O:35])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 22632900HCID 22632900, compound

Product 1

HCID 22632928HCID 22632928, compoundYield 65.9%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using the General Method 6A, the reaction of 10% Pd/C (0.07 g) with 1-(3-fluorophenyl)-6-fluoro-3-benzyloxy-7-(4-methylpiperazin-1-yl)-1H-quinazoline-2,4-dione (Example Z-1, 0.209 g, 0.43 mmol) provided 0.11 g of the title compound as a solid, mp 176-178° C.

Sources & evidence

ORD record
ord-3630708268ed44bf8585e85c51e51b07
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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