HCID 22632990, compound → HCID 22633036, compound

HRID 2270290Notes

Reaction equation

HRID 2270290 reaction equation
[CH2:1]([N:8]1[C:13]2[N:14]=[C:15]([N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)[C:16]([F:18])=[CH:17][C:12]=2[C:11](=[O:24])[N:10]([O:25]CC2C=CC=CC=2)[C:9]1=[O:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.C(OCC)(=O)C.[Pd]>[CH2:1]([N:8]1[C:13]2[N:14]=[C:15]([N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)[C:16]([F:18])=[CH:17][C:12]=2[C:11](=[O:24])[N:10]([OH:25])[C:9]1=[O:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 1

HCID 22632990HCID 22632990, compound

Product 1

HCID 22633036HCID 22633036, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Following the procedure of Example 32, hydrogenation of 1-benzyl-3-benzyloxy-6-fluoro-7-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidine-2,4-dione (Example A-3, 110 mg, 0.247 mmol) and 10% Pd/C (15 mg) in MeOH (2 mL) and ethyl acetate (3 mL) afforded 67 mg, of the title compound as a solid, mp 219-220° C.

Workup

  1. customafforded 67 mg

Sources & evidence

ORD record
ord-46b7cdb042e242b29de505f81d9e534a
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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