HCID 22632877, compound → HCID 22633031, compound

HRID 2270303Notes

Reaction equation

HRID 2270303 reaction equation
C([O:8][N:9]1[C:18](=[O:19])[C:17]2[C:12](=[CH:13][C:14]([N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[C:15]([F:20])[CH:16]=2)[N:11]([CH2:26][CH:27]2[CH2:29][CH2:28]2)[C:10]1=[O:30])C1C=CC=CC=1>C1COCC1.[Pd]>[CH:27]1([CH2:26][N:11]2[C:12]3[C:17](=[CH:16][C:15]([F:20])=[C:14]([N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)[CH:13]=3)[C:18](=[O:19])[N:9]([OH:8])[C:10]2=[O:30])[CH2:29][CH2:28]1

Participants

4

Reactant 1

HCID 22632877HCID 22632877, compound

Product 1

HCID 22633031HCID 22633031, compoundYield 48.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Using the method of Example 56, 20% Pd/C (25 mg), 3-benzyloxy-1-cyclopropylmethyl-6-fluoro-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione (Example V-4, 0.16 g, 0.39 mmol) were combined in 25 mL of THF, to give 0.06 g of the title compound as a solid, mp 211-213° C.

Sources & evidence

ORD record
ord-61438692304c4d0c952abccc11ab41ea
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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