Potassium Carbonate → HCID 12052028, compound

To stirred solution of 4-methoxybenzenethiol (2.8 gm, 20 mmol) and anhydrous K2CO3 (10 gm, excess) in dry acetone (100 ml), ethyl 2-bromo-propionate (3.6 gm, 20 mmol) was added in a round bottom flask and the reaction mixture was heated at reflux for 8 hours with good stirring. At the end, reaction was allowed to cool and the potassium salts were filtered off and the reaction mixture was concentrated. The residue was extracted with chloroform and washed with H2O and 0.5 N NaOH solution. The organic layer was further washed well with water, dried over MgSO4, filtered and concentrated to afford 2-(4-methoxy-phenylsulfanyl)-propionic acid ethyl ester as a light yellow oil. Yield 4.5 gms (94%); MS; 241 (M+H)+.

1. additionwas added in a round bottom flask
2. temperaturethe reaction mixture was heated
3. temperatureat reflux for 8 hours with good stirring
4. customAt the end, reaction
5. temperatureto cool
6. filtrationthe potassium salts were filtered off
7. concentrationthe reaction mixture was concentrated
8. extractionThe residue was extracted with chloroform
9. washwashed with H2O and 0.5 N NaOH solution
10. washThe organic layer was further washed well with water
11. dry with materialdried over MgSO4
12. filtrationfiltered
13. concentrationconcentrated

ORD record

ord-308b3bc973da42a2a391b59ef9ce9966

Source dataset

uspto-grants-2001_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06331563B1