反应详情

Experimental conditions analogous to those described for Step 6 of Example 60 from 120 mg (0.30 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 1.3 mL 0.5M 4-methoxy-3-methylphenylmagnesium bromide. Yield: 102 mg of a white solid. LC-MSD, m/z for C24H19BrN2O3 [M+H]+=463.0, 465.0; HPLC retention time: 2.5 min.