Benzyl Bromide → HCID 11782728, compound

HRID 2270337Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:15])[CH:5]([S:7]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)(=[O:9])=[O:8])[CH3:6])[CH3:2].[CH2:16](Br)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:1]([O:3][C:4](=[O:15])[C:5]([CH3:6])([S:7]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)(=[O:8])=[O:9])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH3:2]

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 54394937HCID 54394937, compound

Product 1

HCID 11782728HCID 11782728, compound

Procedure

2-Methyl-3-phenyl-2-(thiophene-2-sulfonyl)-propionic acid ethyl ester was prepared according to the general method as outlined in example 9. Starting from 2-(thiophen-2-sulfonyl)-propionic acid ethyl ester (3.0 g, 12 mmol) and benzyl bromide (2.48 g, 15 mmol). Yield 5.2 g (%); tan oil; MS 339.1 (M+H).

Sources & evidence

ORD record: ord-2921786d81dd4e80a81e5f6aaf92ddb4
Source dataset: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06331563B1

Reaction notes

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