Potassium Carbonate → HCID 10891792, compound

HRID 2270408Notes

Reaction equation

HRID 2270408 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][S:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[CH3:2].C([O-])([O-])=O.[K+].[K+].Br[CH2:22][CH:23]([CH2:26][CH3:27])[CH2:24][CH3:25]>CC(C)=O>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][S:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:22][CH:23]([CH2:26][CH3:27])[CH2:24][CH3:25])=[CH:9][CH:8]=1)[CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 77432Pentane, 3-(bromomethyl)-HCID 3742252Ethyl 2-[(4-hydroxyphenyl)sulfanyl]acetate

Product 1

HCID 10891792HCID 10891792, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To stirred solution of (4Hydroxy-phenylsulfanyl)-acetic acid ethyl ester (2.12 g, 10 mmol), K2CO3 (anhydrous, 10 g) and 1-bromo-2-ethyl butane (3 g, excess) was added in boiling acetone. The reaction mixture was refluxed for 24 hrs and cooled to room temperature. The reaction mixture was filtered and concentrated. The residue obtained was extracted with chloroform; washed well with water and concentrated. The crude product obtained was taken to next step without purification. Yield 2.8 g (94%); (M+H)+ 297.

Workup

  1. additionwas added
  2. temperatureThe reaction mixture was refluxed for 24 hrs
  3. filtrationThe reaction mixture was filtered
  4. concentrationconcentrated
  5. customThe residue obtained
  6. extractionwas extracted with chloroform
  7. washwashed well with water
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-cab3462f99af451186dbde5a7fc908c7
Source dataset
uspto-grants-2001_12
Patent number
US06331563B1

Reaction notes

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