反应详情

温度

27.5 °C

To a solution of 7-ethyltryptophol (12.0 g) in 1-butanolic hydrogen chloride (5% w/v, 100.0 ml), methyl 3-oxopentanoate (9.1 g) was added in one lot, at 25° C. The reaction mixture was stirred at 25-30° C. for 7 hours. The reaction mixture was extracted with hexane (100.0 ml). Hexane was concentrated to about 20 ml and methanol (10 ml) was added. The product was filtered, washed with methanol and dried to afford the titled compound (14.7 g, 79%), m.p. 128-130° C.; purity: 96.2%.

1. extractionThe reaction mixture was extracted with hexane (100.0 ml)
2. concentrationHexane was concentrated to about 20 ml and methanol (10 ml)
3. additionwas added
4. filtrationThe product was filtered
5. washwashed with methanol
6. customdried