Pyridine → Tetralin

HRID 2270492Notes

Reaction equation

FC(F)(F)S(OS(C(F)(F)F)(=O)=O)(=O)=O.C(Cl)Cl.N1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:20]1[C:24]2[C:24](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:23][CH2:22][CH2:21]1

Participants

Reactant 3

HCID 1049Pyridine

HCID 6344Dichloromethane

HCID 67749Trifluoromethanesulfonic anhydride

Product 1

HCID 8404Tetralin

Procedure

In Step 3, A-3 is reacted with trifluoromethanesulfonic anhydride in the presence of methylene chloride and pyridine to provide A-4 tetralin.

Sources & evidence

ORD record: ord-c1361c4da2a945558e1b87af5c2cb55f
Source dataset: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06331636B1

Reaction notes

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