Hydrochloric Acid → HCID 18331747, compound

HRID 2270499Notes

Reaction equation

HRID 2270499 reaction equation
C[O:2][C:3]([C:5]1[C:14]2[CH2:13][CH:12]([N:15]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[CH2:11][CH2:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+].O.Cl>CO>[N:15]1([CH:12]2[CH2:13][C:14]3[C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=[CH:8][C:9]=3[CH2:10][CH2:11]2)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 54506366HCID 54506366, compound

Product 1

HCID 18331747HCID 18331747, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
75 °C

Procedure

A mixture of 1.56 g 7-(1-Hexahydroazepinyl)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester, 1.57 mL 12 N NaOH, 1.57 mL water in 10 mL methanol was refluxed (70-80° C.) overnight. TLC showed no starting material remaining. The mixture was neutralized with 6 N HCl to pH 5-6 and concentrated to dryness using toluene and methanol. A white solid was recovered and used crude.

Workup

  1. concentrationconcentrated to dryness
  2. customA white solid was recovered

Sources & evidence

ORD record
ord-5e3728c438124745a9f4e3fa3ff2453a
Source dataset
uspto-grants-2001_12
Patent number
US06331636B1

Reaction notes

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