Trifluoroacetic acid → HCID 18331440, compound

HRID 2270552Notes

Reaction equation

HRID 2270552 reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:11]=[C:12]([NH:16][C:17]2[S:18][C:19]([CH3:22])=[CH:20][N:21]=2)[CH:13]=[CH:14][CH:15]=1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[NH2:8][CH2:9][C:10]1[CH:11]=[C:12]([NH:16][C:17]2[S:18][C:19]([CH3:22])=[CH:20][N:21]=2)[CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18331459HCID 18331459, compound

Product 1

HCID 18331440HCID 18331440, compoundYield 68.8%

Procedure

A mixture of the compound (73 mg) obtained in Example 507 and trifluoroacetic acid (5 ml) was stirred at room temperature for 1 h and concentrated under reduced pressure. The resulting residue was purified by basic silica gel column chromatography (eluent, methylene chloride:methanol=95:5) to give 34.5 mg of the titled compound (yield, 67%).

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe resulting residue was purified by basic silica gel column chromatography (eluent, methylene chloride:methanol=95:5)

Sources & evidence

ORD record
ord-ae9fdb8c0120413599ae4555c1c6a0ec
Source dataset
uspto-grants-2001_12
Patent number
US06331553B1

Reaction notes

Loading…