反应详情

Experimental conditions analogous to those described for Step 6 of Example 60 from 120 mg (0.30 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 153 mg (0.66 mmol) of 2-ethyl-5-iodo-pyridine in 1 mL THF with 0.34 mL 2M isopropylmagnesium chloride. Yield: 62 mg of a white powder. LC-MSD, m/z for C23H18BrN3O2 [M+H]+=448.0, 450.0; HPLC retention time: 1.6 min.