HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide → 1-(6-Bromo-pyridin-2-ylmethyl)-3-(4-fluoro-3-methyl-benzoyl)-1H-quinolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide | HCID 57754532 | — |
| Reactant | HCID 178427974 | HCID 178427974 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(6-Bromo-pyridin-2-ylmethyl)-3-(4-fluoro-3-methyl-benzoyl)-1H-quinolin-4-one | HCID 57754671 | — |
Reaction Steps
Experimental conditions analogous to those described for Step 6 of Example 60 from 90 mg (0.22 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 2 mL THF and 0.49 mL 1M 4-fluoro-3-methylphenylmagnesium bromide. Yield: 40 mg of a white solid. LC-MSD, m/z for C23H16BrFN2O2 [M+H]+=451.0, 453.0; HPLC retention time: 2.5 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-7cee6127f44a402fa38e51273c5f5cad |
| Source note | uspto-grants-2009_07 |