反应详情

Experimental conditions analogous to those described for Step 6 of Example 60 from 90 mg (0.22 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 2 mL THF and 0.49 mL 1M 4-fluoro-3-methylphenylmagnesium bromide. Yield: 40 mg of a white solid. LC-MSD, m/z for C23H16BrFN2O2 [M+H]+=451.0, 453.0; HPLC retention time: 2.5 min.