Benzo(B)Thiophene → MLS002608206

HRID 2270676Notes

Reaction equation

HRID 2270676 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2.[Li]C(C)(C)C.[CH3:15][N:16]([CH3:25])[C:17]1[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][CH:18]=1>C1COCC1>[S:1]1[C:5]([CH:21]([OH:22])[C:20]2[CH:19]=[CH:18][C:17]([N:16]([CH3:15])[CH3:25])=[CH:24][CH:23]=2)=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 7221Benzo(B)ThiopheneHCID 74794-(Dimethylamino)BenzaldehydeHCID 178418306HCID 178418306, compound

Product 1

HCID 237069MLS002608206

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

a-(2-benzo[b]thienyl)-4-dimethylaminobenzyl alcohol was prepared by the method of Example 40A with benzo[b]thiophene (7.5 mmoles, 1.0 g), t-BuLi (1.7 M, 8.9 mmoles, 5.3 ml), 4-dimethylaminobenzaldehyde (8.9 mmoles, 1.3 g) and THF (20 ml). The crude product (2.4 g) was carried forward without further purification.

Workup

  1. customThe crude product (2.4 g) was carried forward without further purification

Sources & evidence

ORD record
ord-61c037b3071c4724b4d3656421170492
Source dataset
uspto-grants-2001_12
Patent number
US06331637B1

Reaction notes

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