4-Bromo-3-methylisoxazol-5-amine → Ammonium Hydroxide

HRID 2270700Notes

Reaction equation

HRID 2270700 reaction equation
Cl[S:2]([C:5]1[S:6][C:7]([C:10]2[CH:11]=[C:12]([CH3:16])[CH:13]=[CH:14][CH:15]=2)=[CH:8][CH:9]=1)(=[O:4])=[O:3].[NH2:17][C:18]1[O:22][N:21]=[C:20]([CH3:23])[C:19]=1[Br:24]>>[Br:24][C:19]1[C:20]([CH3:23])=[N:21][O:22][C:18]=1[NH:17][S:2]([C:5]1[S:6][C:7]([C:10]2[CH:11]=[C:12]([CH3:16])[CH:13]=[CH:14][CH:15]=2)=[CH:8][CH:9]=1)(=[O:4])=[O:3].[NH4+:17].[OH-:3]

Participants

4

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 22998416HCID 22998416, compound

Product 2

HCID 14923Ammonium HydroxideHCID 23445439HCID 23445439, compound

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-5-(3-tolyl)thiophene-2-sulfonamide was prepared in the same manner as described in the Example 116C using 2-chlorosulfonyl-5-(3-tolyl)thiophene and 5-amino-4-bromo-3-methylisoxazole. To obtain the ammonium salt of the final product, aqueous NH4OH was used (31% yield; hygroscopic).

Workup

  1. customN-(4-bromo-3-methyl-5-isoxazolyl)-5-(3-tolyl)thiophene-2-sulfonamide was prepared in the same manner

Sources & evidence

ORD record
ord-05c1c1df66484c8490f1900f54d6e83f
Source dataset
uspto-grants-2001_12
Patent number
US06331637B1

Reaction notes

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