HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(6-Methyl-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl amide → 3-(4-Dimethylamino-benzoyl)-1-(6-methyl-pyridin-2-ylmethyl)-1H-quinolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(6-Methyl-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl amide | HCID 57754512 | — |
| Solvent | Bromide ion | HCID 259 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(4-Dimethylamino-benzoyl)-1-(6-methyl-pyridin-2-ylmethyl)-1H-quinolin-4-one | HCID 57754713 | — |
Reaction Steps
Experimental conditions analogous to those described for Step 6 of Example 60, from 138 mg (0.41 mmol) of 1-(6-methyl-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 2 mL THF and 2 mL 0.5M 4-N,N-dimethylanilinemagnesium bromide. Yield: 17 mg of a white solid. LC-MSD, m/z for C25H23N3O2 [M+H]+=398.1; HPLC retention time: 1.9 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-1e4db1be7c4f440ebbb135e865d1da2f |
| Source note | uspto-grants-2009_07 |