反应详情

Experimental conditions analogous to those described for Step 6 of Example 60, from 138 mg (0.41 mmol) of 1-(6-methyl-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 2 mL THF and 2 mL 0.5M 4-N,N-dimethylanilinemagnesium bromide. Yield: 17 mg of a white solid. LC-MSD, m/z for C25H23N3O2 [M+H]+=398.1; HPLC retention time: 1.9 min.