HCID 20714641, compound → N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine

HRID 2270761Notes

Reaction equation

HRID 2270761 reaction equation
Br[C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH:9][CH2:10][C@@H:11]([C:33]([OH:35])=[O:34])[NH:12][C:13](=[O:32])[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([OH:30])[CH:25]=2)=[O:21])=[CH:16][C:15]=1[Cl:31])=[O:8].BrC1SC(C(NC[C@@H](C(O)=O)NC(=O)C2C=CC(C(NCC3C=CC=C(O)C=3)=O)=CC=2Cl)=O)=CC=1.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC=CC=1Cl)=O)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC(Cl)=CC=1)=O)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC(Br)=C(Br)C=1)=O)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC=CC=1C)=O)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1SC(C)=CC=1)=O)=O.ClC1C=C(C(NCC2C=CC=C(O)C=2)=O)C=CC=1C(N[C@H](C(O)=O)CNC(C1C=CSC=1)=O)=O>>[Cl:31][C:15]1[CH:16]=[C:17]([C:20]([NH:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([OH:30])[CH:25]=2)=[O:21])[CH:18]=[CH:19][C:14]=1[C:13]([NH:12][C@H:11]([C:33]([OH:35])=[O:34])[CH2:10][NH:9][C:7]([C:3]1[S:4][CH:5]=[CH:6][CH:2]=1)=[O:8])=[O:32]

Participants

9

Reactant 8

HCID 20714641HCID 20714641, compoundHCID 20714643HCID 20714643, compoundHCID 20714644HCID 20714644, compoundHCID 20714645HCID 20714645, compoundHCID 20714646HCID 20714646, compoundHCID 20714659HCID 20714659, compoundHCID 68819182HCID 68819182, compoundHCID 68820442HCID 68820442, compound

Product 1

HCID 60115134N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-(thiophene-2-carbonyl)amino-L-alanine

Procedure

3-(3-bromothiophene-2-carbonyl)amino-N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-L-alanine; 3-(5-bromothiophene-2-carbonyl)amino-N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3-chlorothiophene-2-carbonyl)]amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(5-chlorothiophene-2-carbonyl)]amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(4,5-dibromothiophene-2-carbonyl)]amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3-methylthiophene-2-carbonyl)]amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(5-methylthiophene-2-carbonyl)]amino-L-alanine; N-[2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(thiophene-3-carbonyl)]amino-L-alanine).

Sources & evidence

ORD record
ord-fd85592aae9e42a48572d50aa4401143
Source dataset
uspto-grants-2001_12
Patent number
US06331640B1

Reaction notes

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