2-Chloro-4-[1-oxo-3-(3-hydroxyphenyl)propyl]benzoic acid → 2-Chloro-4-(1-hydroxy-3-(3-hydroxyphenyl)propyl)benzoic acid

HRID 2270812Notes

Reaction equation

HRID 2270812 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([CH:12]([OH:22])[CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([OH:21])[CH:16]=2)[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].ClC1C=C(C(=O)CCC2C=CC=C(O)C=2)C=CC=1C(O)=O>>[Cl:1][C:2]1[CH:11]=[C:10]([CH:12]([OH:22])[CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([OH:21])[CH:16]=2)[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 226613772-Chloro-4-[1-oxo-3-(3-hydroxyphenyl)propyl]benzoic acidHCID 235607782-Chloro-4-[1-hydroxy-3-(3-hydroxyphenyl)propyl]benzoic acid, methyl ester

Product 1

HCID 226612282-Chloro-4-(1-hydroxy-3-(3-hydroxyphenyl)propyl)benzoic acid

Procedure

This compound was prepared in90% yield from 2-chloro-4-[1-hydroxy-3-(3-hydroxyphenyl)propyl]benzoic acid, methyl ester (Example 19) by the procedure described for 2-chloro-4-[1-oxo-3-(3-hydroxyphenyl)propyl]benzoic acid (Example 41). The product was a racemic mixture and was not resolved.

Workup

  1. customThis compound was prepared in90%

Sources & evidence

ORD record
ord-9fd90d3563ee4146a0927c390c5c70fc
Source dataset
uspto-grants-2001_12
Patent number
US06331640B1

Reaction notes

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