Hydrazinecarboxaldehyde → HCID 53660506, compound

HRID 2270899Notes

Reaction equation

HRID 2270899 reaction equation
[CH:1]([NH:3][NH2:4])=[O:2].[Cl:5][C:6]1[C:11]([O:12][C:13]2[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:10][C:9]([N:23]=[C:24]=[S:25])=[C:8]([F:26])[CH:7]=1>O1CCCC1>[Cl:5][C:6]1[C:11]([O:12][C:13]2[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:10][C:9]([NH:23][C:24]([N:3]([CH:1]=[O:2])[NH2:4])=[S:25])=[C:8]([F:26])[CH:7]=1

Participants

4

Reactant 2

HCID 12229HydrazinecarboxaldehydeHCID 18402951HCID 18402951, compound

Product 1

HCID 53660506HCID 53660506, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Formic hydrazide (0.6 g) was added to a mixture of 4-chloro-2-fluoro-5-(3-trifluoromethyl-2-pyridyloxy)phenyl isothiocyanate (3.4 g) in tetrahydrofuran (20 ml) and the mixture was stirred for 3 hours at room temperature. The solvent was removed under reduced pressure and the residue processed. The resulting oil was dissolved in ethanol (30 ml), and hexane added to induce crystallization. The crystals were filtered and dried to give the product, (3.5 g, 69%).

Workup

  1. customThe solvent was removed under reduced pressure
  2. dissolutionThe resulting oil was dissolved in ethanol (30 ml)
  3. additionhexane added
  4. customcrystallization
  5. filtrationThe crystals were filtered
  6. customdried
  7. customto give the product, (3.5 g, 69%)

Sources & evidence

ORD record
ord-7e2f818823a24527bb18c77efc6d317c
Source dataset
uspto-grants-2001_12
Patent number
US06333296B1

Reaction notes

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