Dimethylamine → 1-(3-Chloro-benzyl)-3-(6-dimethylamino-pyridine-3-carbonyl)-1H-quinolin-4-one

HRID 227092Notes

Reaction equation

HRID 227092 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[C:8]([C:17]([C:19]2[CH:20]=[N:21][C:22](Cl)=[CH:23][CH:24]=2)=[O:18])=[CH:7]1.[CH3:29][NH:30][CH3:31]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[C:8]([C:17]([C:19]2[CH:20]=[N:21][C:22]([N:30]([CH3:31])[CH3:29])=[CH:23][CH:24]=2)=[O:18])=[CH:7]1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 577546041-(3-Chloro-benzyl)-3-(6-chloro-pyridine-3-carbonyl)-1H-quinolin-4-one

Product 1

HCID 577547701-(3-Chloro-benzyl)-3-(6-dimethylamino-pyridine-3-carbonyl)-1H-quinolin-4-one

Procedure

Experimental conditions analogous to those described for Example 141, from 151 mg (0.37 mmol) of 1-(3-chloro-benzyl)-3-(6-chloro-pyridine-3-carbonyl)-1H-quinolin-4-one and 2 mL 2 M dimethylamine solution. Yield: 127 mg of a yellow powder. LC-MSD, m/z for C24H20ClN3O2 [M+H]+=418.1, 420.1; HPLC retention time: 1.6 min.

Sources & evidence

ORD record
ord-496b1a7e1216467896062fef38e18274
Source dataset
uspto-grants-2009_07
Patent number
US07557213B2

Reaction notes

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