1,3-Benzodioxol-5-amine → HCID 178500748, compound

HRID 227098Notes

Reaction equation

HRID 227098 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C:4]([C:8](=[O:17])[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]=1)=[CH:5]OC.[O:19]1[C:23]2[CH:24]=[CH:25][C:26]([NH2:28])=[CH:27][C:22]=2[O:21][CH2:20]1>>[CH3:1][O:2][C:3](=[O:18])[C:4]([C:8](=[O:17])[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]=1)=[CH:5][NH:28][C:26]1[CH:25]=[CH:24][C:23]2[O:19][CH2:20][O:21][C:22]=2[CH:27]=1

Participants

3

Reactant 2

HCID 843101,3-Benzodioxol-5-amineHCID 668792722-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester

Product 1

HCID 178500748HCID 178500748, compound

Procedure

Experimental conditions analogous to those described for Step 1 of Example 1, from crude 2-(3,4-dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester (4.03 g, 16.3 mmol) and benzo[1,3]dioxol-5-ylamine (2.45 g, 17.9 mmol). Yield: 3.14 g of a yellow crystalline solid: LC-MSD, m/z for C20H20NO5 [M+H]+=354.4; HPLC retention time: 2.8 min.

Sources & evidence

ORD record
ord-1ad55c094682467f9bc8094d3149fa6e
Source dataset
uspto-grants-2009_07
Patent number
US07557213B2

Reaction notes

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