Phosphorus oxychloride → 4-chloro-5-nitropyrimidin-2-amine

HRID 2270990Notes

Reaction equation

HRID 2270990 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](O)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.P(Cl)(Cl)([Cl:14])=O>>[NH2:1][C:2]1[N:7]=[C:6]([Cl:14])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178508524HCID 178508524, compound

Product 1

HCID 3199954-chloro-5-nitropyrimidin-2-amine

Procedure

A suspension of 2-amino-4-hydroxy-5-nitropyrimidine (5.0 g, 32.1 mmol) in phosphorous oxychloride (100 mL) was refluxed overnight, and the excess phosphorous oxychloride was evaporated under reduced pressure. The residue was mixed with ice (100 g) in an ice-bath, and the mixture was neutralized with concentrated aqueous sodium carbonate solution. A yellow precipitate was collected by filtration and washed with water: yield, 1.39 g (25%); mp 191-194° C. dec.; 1H NMR d 8.45 (br s, 2 H, NH2, exchange with D2O), 9.03 (s, 1 H, H-6); MS (EI) calcd. m/z for C4H3N4O235Cl 173.9944, found 173.9934; calcd. m/z for C4H3N4O237Cl 175.9915, found 175.9916.

Workup

  1. temperaturewas refluxed overnight
  2. customthe excess phosphorous oxychloride was evaporated under reduced pressure
  3. additionThe residue was mixed with ice (100 g) in an ice-bath
  4. filtrationA yellow precipitate was collected by filtration
  5. washwashed with water
  6. customyield

Sources & evidence

ORD record
ord-09b2493ab9fb4f149b2634d14d46c6f4
Source dataset
uspto-grants-2001_12
Patent number
US06333331B1

Reaction notes

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