Hydrochloric Acid → HCID 18387567, compound

HRID 2271005Notes

Reaction equation

HRID 2271005 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][S:5]([N:8]1[CH2:13][CH2:12][N:11]([S:14]([CH3:17])(=[O:16])=[O:15])[CH2:10][CH:9]1[C:18]([O:20]CC)=[O:19])(=[O:7])=[O:6].[OH-].[Na+].Cl>O1CCOCC1.CCO>[Cl:1][CH2:2][CH2:3][CH2:4][S:5]([N:8]1[CH2:13][CH2:12][N:11]([S:14]([CH3:17])(=[O:15])=[O:16])[CH2:10][CH:9]1[C:18]([OH:20])=[O:19])(=[O:7])=[O:6]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54354261HCID 54354261, compound

Product 1

HCID 18387567HCID 18387567, compoundYield 87.8%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A mixture of ethyl (2RS)-1-(3-chloropropylsulfonyl)-4-methanesulfonylpiperazine-2-carboxylate (203 mg) and 1N aqueous sodium hydroxide (0.9 ml) in dioxane (2 ml) and EtOH (1 ml) was stirred for 2 hours at ambient temperature. The mixture was acidified with 1N HCl (0.9 ml) and concentrated in vacuo. The resulting crystals were collected with H2O, and washed with H2O and Et2O to give 165 mg of (2RS)-1-(3-chloropropylsulfonyl)-4-methanesulfonylpiperazine-2-carboxylic acid.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe resulting crystals were collected with H2O
  3. washwashed with H2O and Et2O

Sources & evidence

ORD record
ord-3af2b34874784e89a336e0d8d95c2a2d
Source dataset
uspto-grants-2001_12
Patent number
US06333324B1

Reaction notes

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