2,5-Dibromopyridine → HCID 18329832, compound

Temperature

100 °C

Azetidine hydrochloride (3.0 g, 32.1 mmol) was added to a solution of sodium (0.73 g, 31.7 mmol) in ethanol (25 ml) and the solution stirred vigorously for an hour. 2,5-Dibromopyridine (5.0 g, 21.1 mmol) was then added and the reaction mixture heated at 100° C. for 10 hours in a sealed vessel, and then at 120° C. for a further 10 hours. The cooled mixture was concentrated under reduced pressure and the residue was partitioned between water and ethyl acetate. The layers were separated, the aqueous phase was extracted with ethyl acetate (3×), and the combined organic extracts washed with brine, dried (MgSO4), and evaporated under reduced pressure. The crude product was purified by medium pressure column chromatography on silica gel, using dichloromethane:pentane (66:34) as eluant to give the tile compound, (900 mg, 17%) as white crystals.

1. concentrationThe cooled mixture was concentrated under reduced pressure
2. customthe residue was partitioned between water and ethyl acetate
3. customThe layers were separated
4. extractionthe aqueous phase was extracted with ethyl acetate (3×)
5. washthe combined organic extracts washed with brine
6. dry with materialdried (MgSO4)
7. customevaporated under reduced pressure
8. customThe crude product was purified by medium pressure column chromatography on silica gel
9. customto give the tile compound, (900 mg, 17%) as white crystals

ORD record

ord-481b97ac3b7b42a3a3071aa5a87dd76b

Source dataset

uspto-grants-2001_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06333330B1