Thiourea → HCID 18330792, compound

HRID 2271235Notes

Reaction equation

HRID 2271235 reaction equation
[C:1]([O:9][CH:10]([CH2:17][CH3:18])[C:11](=O)[C:12]([CH3:15])([CH3:14])[CH3:13])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:19]C(N)=S>CN(C)C=O>[C:2]1([C:1]2[O:9][C:10]([CH2:17][CH3:18])=[C:11]([C:12]([CH3:15])([CH3:14])[CH3:13])[N:19]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 18330794HCID 18330794, compound

Product 1

HCID 18330792HCID 18330792, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
160 °C

Procedure

0.31 g of 1-ethyl-3,3-dimethyl-2-oxobutyl benzoate is dissolved in 8 ml of dimethylformamide in a reactor. 0.75 g of thiourea (5 eq.) is subsequently added and the reaction mixture is left to react at reflux (160° C.) for 6 hours. The reaction mixture is extracted with dichloromethane and then washed 3 times with water, dried over anhydrous sodium sulphate, filtered and finally brought to dryness under vacuum.

Workup

  1. waitthe reaction mixture is left
  2. customto react
  3. extractionThe reaction mixture is extracted with dichloromethane
  4. washwashed 3 times with water
  5. dry with materialdried over anhydrous sodium sulphate
  6. filtrationfiltered

Sources & evidence

ORD record
ord-1a58fe11e04248858fcdb16adf208429
Source dataset
uspto-grants-2001_12
Patent number
US06333414B1

Reaction notes

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