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HRID2271275

反应详情

EQUATION

反应方程式

HRID 2271275 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCOC(=O)c1cn(C2CC2)c2cc(F)c(F)c(C)c2c1=O
HCID14651255

未命名化合物

PRODUCTS

生成物

1
结构：Cc1c(F)c(F)cc2c1c(=O)c(C(=O)O)cn2C1CC1
HCID14651254

1-Cyclopropyl-6,7-difluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

C14H11F2NO3

收率 92.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

20 ml of 90% acetic acid and 5 ml of concentrated hydrochloric acid were added to 1.9 g of ethyl 1-cyclopropyl-6,7-difluoro-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate, followed by refluxing for 2 hours. After cooling, the crystals precipitated were collected by filtration and washed with water, followed by washing with ethanol and then with diethyl ether to give 1.6 g of 1-cyclopropyl-6,7-difluoro-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid.

WORKUP

后处理

  1. temperatureby refluxing for 2 hours
  2. temperatureAfter cooling
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. washwashed with water
  6. washby washing with ethanol