Morpholine → HCID 4585434, compound

HRID 2271391Notes

Reaction equation

HRID 2271391 reaction equation
[C:1]1([CH:7](Br)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH:7]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 8471TriethylamineHCID 236603Bromodiphenylmethane

Product 1

HCID 4585434HCID 4585434, compoundYield 14%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Diphenylmethyl bromide (211 mg, 0.877 mmol) was added to a solution of morpholine (23.9 μL, 0.274 mmol), triethylamine (130 μL, 0.932 mmol) and chloroform (1.4 mL) and was allowed to stir at room temperature. After 48 hr, the reaction mixture was concentrated in vacuo and the resulting crude mixture was purified by column chromatography (10% ethyl acetate/hexanes) to provide the title compound in 14% yield.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. customthe resulting crude mixture was purified by column chromatography (10% ethyl acetate/hexanes)

Sources & evidence

ORD record
ord-fee12b97c0ea40b6aee4c63721f06aee
Source dataset
uspto-grants-2015_09
Patent number
US09120744B2

Reaction notes

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