Diisopropylethylamine → HCID 56645960, compound

HRID 2271394Notes

Reaction equation

HRID 2271394 reaction equation
[F:1][C:2]1[CH:28]=[CH:27][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[N:18]=[C:17]([C:19]([N:21]4[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]4)=[O:20])[CH:16]=[CH:15][CH:14]=3)=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH3:29][S:30]([C:33]1[CH:34]=[C:35]([S:39](Cl)(=[O:41])=[O:40])[CH:36]=[CH:37][CH:38]=1)(=[O:32])=[O:31].CCN(C(C)C)C(C)C>C(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]([C:13]3[N:18]=[C:17]([C:19]([N:21]4[CH2:26][CH2:25][N:24]([S:39]([C:35]5[CH:36]=[CH:37][CH:38]=[C:33]([S:30]([CH3:29])(=[O:32])=[O:31])[CH:34]=5)(=[O:41])=[O:40])[CH2:23][CH2:22]4)=[O:20])[CH:16]=[CH:15][CH:14]=3)=[CH:11][CH:12]=2)=[CH:27][CH:28]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 2203303-(Methylsulfonyl)benzenesulfonyl chlorideHCID 66666822HCID 66666822, compound

Product 1

HCID 56645960HCID 56645960, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

According to the methodology described in Example 7, compound 6 (100 mg, 0.24 mmol), 3-methylsulfonylbenzenesulfonyl chloride (60 mg, 0.24 mmol), DIEA (0.1 mL, 0.7 mmol) and DCM (5 mL) were reacted to give compound 8 in 84% yield (LC/MS (m/z+H)=596; 1H NMR (CDCl3) δ ppm: 6.8-8.5 (m, 15H); 4.0 (m, 4H); 3.3 (m, 4H); 3.2 (s, 3H)).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-7e5caf38d3914ffba042a378e6c0ee43
Source dataset
uspto-grants-2015_09
Patent number
US09120752B2

Reaction notes

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