Methyl iodide → 1-Bromo-2-methoxy-3-nitrobenzene

Temperature

70 °C

2-Bromo-6-nitro-phenol 1b (46.55 g, 0.214 mol) was dissolved in 500 mL of acetone followed by addition of potassium carbonate (35.36 g, 0.26 mol) and iodomethane (20.1 mL, 0.32 mol). The reaction mixture was heated to reflux at 70° C. for 40 hours. The reaction mixture was concentrated under reduced pressure and diluted with 1300 mL of ethyl acetate and 500 mL of water. The aqueous layer was extracted with ethyl acetate (300 mL×2). The combined organic extracts were washed with 4 M hydrochloric acid and saturated sodium bicarbonate solution and then dried over anhydrous magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain the title compound 1-bromo-2-methoxy-3-nitro-benzene 1e (44.59 g, yield 90.0%) as a brown solid.

1. temperatureThe reaction mixture was heated
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. additiondiluted with 1300 mL of ethyl acetate and 500 mL of water
4. extractionThe aqueous layer was extracted with ethyl acetate (300 mL×2)
5. washThe combined organic extracts were washed with 4 M hydrochloric acid and saturated sodium bicarbonate solution
6. dry with materialdried over anhydrous magnesium sulfate
7. filtrationfiltered
8. concentrationthe filtrate was concentrated under reduced pressure
9. customThe resulting residue was purified by silica gel column chromatography

ORD record

ord-9df1b5ea6fc842658e064bac41d2ba4d

Source dataset

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09120762B2