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HRID2271445

反应详情

EQUATION

反应方程式

HRID 2271445 的结构方程式

REACTANTS

反应物

3
结构：CO
HCID887

Methanol

CH4O

结构：CC1=NN(c2ccc3c(c2)CCCC3)C(=O)/C1=N\Nc1cccc(-c2ccc(C(=O)O)o2)c1O
HCID178433810

未命名化合物

结构：CC1=NN(c2ccc3c(c2)CCCC3)C(=O)C1=NNc1cccc(-c2ccoc2C(=O)O)c1O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
HCID178433819

未命名化合物

PRODUCTS

生成物

2
结构：CC1=NN(c2ccc3c(c2)CCCC3)C(=O)/C1=N\Nc1cccc(-c2ccc(C(=O)O)o2)c1O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
HCID178433815

未命名化合物

收率 134.9%
结构：CC1=NN(c2ccc3c(c2)CCCC3)C(=O)C1=NNc1cccc(-c2ccoc2C(=O)O)c1O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
HCID178433819

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

(Z)-5-(2-hydroxy-3-{N′-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydro-naphthalen-2-yl)-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-phenyl)-furan-2-carboxylic acid 7d (100 mg, 0.22 mmol) was suspended in 5 mL of tetrahydrofuran to form a dark red suspension. The reaction mixture was added with meglumine (85 mg, 0.44 mmol), and stirred at room temperature overnight. The resulting solution was added with 4 mL of methanol and concentrated under reduced pressure to obtain the title compound (Z)-5-(2-hydroxy-3-{N′-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydro-naphthalen-2-yl)-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-phenyl)-furan-2-carboxylic acid bis-(meglumine) 10 (168 mg, yield: 90.8%) as a dark red solid.

WORKUP

后处理

  1. customto form a dark red suspension
  2. concentrationconcentrated under reduced pressure