1-(6-Bromo-4-chloroquinolin-3-YL)ethanone → Tert-butyl (1-(5-((3-acetyl-6-bromoquinolin-4-yl)amino)pyridin-2-yl)piperidin-3-yl)(methyl)carbamate

Participants

Reaction Steps

Following general procedure C, 1-(6-bromo-4-chloroquinolin-3-yl)ethanone (285 mg, 1.0 mmol) was reacted with tert-butyl (1-(5-aminopyridin-2-yl)piperidin-3-yl)(methyl)carbamate (442 mg, 1.45 mmol) to afford the desired product (446 mg, 80%) as an orange-red solid. ESI MS m/z 554 [C27H32BrN5O3+H]+

Provenance & Evidence