HCID 178483676, compound → HCID 178483674, compound

HRID 2271568Notes

Reaction equation

HRID 2271568 reaction equation
[CH3:1][N:2]([CH2:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([NH:11]C(=O)OC(C)(C)C)[CH2:7][CH2:6]1)[CH3:3]>Cl>[CH3:3][N:2]([CH2:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([NH2:11])[CH2:7][CH2:6]1)[CH3:1]

Participants

3

Reactant 1

HCID 178483676HCID 178483676, compound

Product 1

HCID 178483674HCID 178483674, compoundYield 148.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Following general procedure A-1, tert-butyl trans-4-[(dimethylamino)methyl]cyclohexylcarbamate (1.1 g, 4.30 mmol) was reacted with 3 M hydrochloric acid (10 mL) to afford the desired product (1.0 g, >99%) as a glass: ESI MS m/z 230 [C9H20N2+H]+.

Sources & evidence

ORD record
ord-a2301d6adfc5418f923fc6b4a0a8aaa8
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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