1-Boc-4-(aminomethyl)piperidine → HCID 68091878, compound

HRID 2271580Notes

Reaction equation

HRID 2271580 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2Cl.[NH2:18][CH2:19][CH:20]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[NH:18][CH2:19][CH:20]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 7368171-Boc-4-(aminomethyl)piperidineHCID 66715111(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone

Product 1

HCID 68091878HCID 68091878, compoundYield 99%

Procedure

Following general procedure B, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (500 mg, 1.60 mmol) was reacted with tert-butyl 4-(aminomethyl)piperidine-1-carboxylate (516 mg, 2.41 mmol) to afford the desired product (80 mg, >99%) as an orange foam: ESI MS m/z 489 [C24H30BrN3O3+H]+.

Sources & evidence

ORD record
ord-06f4b551cce1440784168ccfc6d7570c
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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