4-(Dimethylaminomethyl)piperidine → HCID 66715563, compound

HRID 2271593Notes

Reaction equation

HRID 2271593 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2Cl.[CH3:16][N:17]([CH3:25])[CH2:18][CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2[N:22]1[CH2:23][CH2:24][CH:19]([CH2:18][N:17]([CH3:25])[CH3:16])[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 111372684-(Dimethylaminomethyl)piperidineHCID 667154831-(6-Bromo-4-chloroquinolin-3-YL)ethanone

Product 1

HCID 66715563HCID 66715563, compoundYield 8.1%

Procedure

Following general procedure B, 1-(6-bromo-4-chloroquinolin-3-yl)ethanone (160 mg, 0.560 mmol) was reacted with N,N-dimethyl-1-(piperidin-4-yl)methanamine (172 mg, 0.800 mmol) to afford the desired product (17.7 mg, 8%) as an off-white solid: ESI MS m/z 390 [C19H24BrN3O+H]+.

Sources & evidence

ORD record
ord-45b271ef61bd44e487c2d9226956cea7
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

Loading…