6-(4-Methylpiperazin-1-yl)pyridin-3-amine → HCID 86692873, compound

HRID 2271601Notes

Reaction equation

HRID 2271601 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2Cl.[CH3:16][N:17]1[CH2:22][CH2:21][N:20]([C:23]2[N:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=2)[CH2:19][CH2:18]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2[NH:29][C:26]1[CH:27]=[N:28][C:23]([N:20]2[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 27633906-(4-Methylpiperazin-1-yl)pyridin-3-amineHCID 667154831-(6-Bromo-4-chloroquinolin-3-YL)ethanone

Product 1

HCID 86692873HCID 86692873, compoundYield 29%

Procedure

Following general procedure B, 1-(6-bromo-4-chloroquinolin-3-yl)ethanone (200 mg, 0.704 mmol) was reacted with 6-(4-methylpiperazin-1-yl)pyridin-3-amine (163 mg, 0.845 mmol) to afford the desired product (90 mg, 29%) as a yellow solid: ESI MS m/z 440, [C21H22BrN5O+H]+

Sources & evidence

ORD record
ord-5381185e852d46b0b29d4db77b8047ea
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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