tert-butyl N-(4-oxocyclohexyl)carbamate → HCID 86692878, compound

HRID 2271622Notes

Reaction equation

HRID 2271622 reaction equation
Cl.[F:2][C@@H:3]1[CH2:7][CH2:6][NH:5][CH2:4]1.O=[C:9]1[CH2:14][CH2:13][CH:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11][CH2:10]1>>[F:2][C@@H:3]1[CH2:7][CH2:6][N:5]([CH:9]2[CH2:14][CH2:13][CH:12]([NH2:15])[CH2:11][CH2:10]2)[CH2:4]1

Participants

3

Reactant 2

HCID 1512535tert-butyl N-(4-oxocyclohexyl)carbamateHCID 2759162(3R)-3-fluoropyrrolidine hydrochloride

Product 1

HCID 86692878HCID 86692878, compoundYield 51%

Procedure

Following General procedure I, (R)-3-fluoropyrrolidine hydrochloride (407 mg, 3.26 mmol) was reacted with tert-butyl 4-oxocyclohexylcarbamate (500 mg, 2.34 mmol) to afford the desired product (200 mg, 51%) as a colorless oil: ESI MS m/z 187 [C10H19FN2+H]+.

Sources & evidence

ORD record
ord-127d6a7df3544c36aea14457af7b3c17
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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