tert-butyl N-(4-oxocyclohexyl)carbamate → HCID 66715482, compound

HRID 2271623Notes

Reaction equation

HRID 2271623 reaction equation
Cl.[F:2][C:3]1([F:8])[CH2:7][CH2:6][NH:5][CH2:4]1.O=[C:10]1[CH2:15][CH2:14][CH:13]([NH:16]C(=O)OC(C)(C)C)[CH2:12][CH2:11]1>>[F:2][C:3]1([F:8])[CH2:7][CH2:6][N:5]([CH:10]2[CH2:15][CH2:14][CH:13]([NH2:16])[CH2:12][CH2:11]2)[CH2:4]1

Participants

3

Reactant 2

HCID 1512535tert-butyl N-(4-oxocyclohexyl)carbamateHCID 249034823,3-Difluoropyrrolidine hydrochloride

Product 1

HCID 66715482HCID 66715482, compoundYield 106.1%

Procedure

Following General procedure I, 3,3-difluoropyrrolidine hydrochloride (468 mg, 3.26 mmol) was reacted with tert-butyl 4-oxocyclohexylcarbamate (500 mg, 2.34 mmol) to afford the desired product (507 mg, quant.) as a colorless oil: ESI MS m/z 205 [C10H18F2N2+H]+.

Sources & evidence

ORD record
ord-ab46db9db883481981fef8c8dcd2acdd
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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