4-((4-Methylpiperazin-1-yl)methyl)aniline → HCID 68091904, compound

HRID 2271657Notes

Reaction equation

HRID 2271657 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2Cl.[CH3:18][N:19]1[CH2:24][CH2:23][N:22]([CH2:25][C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)[CH2:21][CH2:20]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[NH:30][C:29]1[CH:28]=[CH:27][C:26]([CH2:25][N:22]2[CH2:21][CH2:20][N:19]([CH3:18])[CH2:24][CH2:23]2)=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 31539964-((4-Methylpiperazin-1-yl)methyl)anilineHCID 66715111(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone

Product 1

HCID 68091904HCID 68091904, compoundYield 56%

Procedure

Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (200 mg, 0.644 mmol) was reacted with 4-[(4-methylpiperazin-1-yl)methyl]aniline (200 mg, 0.966 mmol) to afford the desired product (173 mg, 56%) as a yellow solid: ESI MS m/z 479 [C25H27BrN4O+H]+.

Sources & evidence

ORD record
ord-bb22de33ea4149a5a40356694b1a5e31
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

Loading…