HRID2271698

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID53216587

(3-Chloro-4-hydroxy-5-methoxyphenyl)boronic acid

C7H8BClO4

结构：CC(C)(C)OC(=O)N1CCC2(CCN(c3c(C(=O)C4CC4)cnc4ccc(Br)cc34)CC2)C1

HCID66715811

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2ccc3ncc(C(=O)C4CC4)c(N4CCC5(CCN(C(=O)OC(C)(C)C)C5)CC4)c3c2)cc(Cl)c1O

HCID68091922

未命名化合物

收率 191.5%

PROCEDURE

实验过程

Following general procedure F, tert-butyl 8-[6-bromo-3-(cyclopropanecarbonyl)quinolin-4-yl]-2,8-diazaspiro[4,5]decane-2-carboxylate (50 mg, 0.097 mmol) was reacted with 3-chloro-4-hydroxy-5-methoxyphenylboronic acid (41 mg, 0.161 mmol) to afford the crude product (110 mg) as a brown oil: ESI MS m/z 593 [C33H38ClN3O5+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e86f2e394b97441eb92dba2be705abff
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09120749B2
来源说明: uspto-grants-2015_09

反应 SMILES

Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[N:17]1[CH2:33][CH2:32][C:20]2([CH2:24][N:23]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:22][CH2:21]2)[CH2:19][CH2:18]1.[Cl:34][C:35]1[CH:36]=[C:37](B(O)O)[CH:38]=[C:39]([O:42][CH3:43])[C:40]=1[OH:41]>>[Cl:34][C:35]1[CH:36]=[C:37]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[N:8]=[CH:7][C:6]([C:12]([CH:14]2[CH2:16][CH2:15]2)=[O:13])=[C:5]3[N:17]2[CH2:33][CH2:32][C:20]3([CH2:24][N:23]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:22][CH2:21]3)[CH2:19][CH2:18]2)[CH:38]=[C:39]([O:42][CH3:43])[C:40]=1[OH:41]