HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Chloro-4-hydroxy-5-methoxyphenyl)boronic acid → tert-Butyl 8-[6-(3-chloro-4-hydroxy-5-methoxyphenyl)-3-(cyclopropanecarbonyl)quinolin-4-yl]-2,8-diazaspiro[4,5]decane-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Chloro-4-hydroxy-5-methoxyphenyl)boronic acid | HCID 53216587 | — |
| Reactant | tert-Butyl 8-[6-bromo-3-(cyclopropanecarbonyl)quinolin-4-yl]-2,8-diazaspiro[4,5]decane-2-carboxylate | HCID 66715811 | — |
| Product | tert-Butyl 8-[6-(3-chloro-4-hydroxy-5-methoxyphenyl)-3-(cyclopropanecarbonyl)quinolin-4-yl]-2,8-diazaspiro[4,5]decane-2-carboxylate | HCID 68091922 | 191.5% |
Reaction Steps
Following general procedure F, tert-butyl 8-[6-bromo-3-(cyclopropanecarbonyl)quinolin-4-yl]-2,8-diazaspiro[4,5]decane-2-carboxylate (50 mg, 0.097 mmol) was reacted with 3-chloro-4-hydroxy-5-methoxyphenylboronic acid (41 mg, 0.161 mmol) to afford the crude product (110 mg) as a brown oil: ESI MS m/z 593 [C33H38ClN3O5+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120749B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-e86f2e394b97441eb92dba2be705abff |
| Source note | uspto-grants-2015_09 |