反应详情

Following general procedure A-2, tert-butyl trans-4-[3-(cyclopropanecarbonyl)-6-(3,5-difluoro-4-hydroxyphenyl)quinolin-4-ylamino]cyclohexylcarbamate (26.2 mg, 0.049 mmol) was reacted with TFA (2 mL) to afford the desired product (17 mg, 79%) as a yellow solid: 1H NMR (300 MHz, CD3OD) δ 9.14 (s, 1H), 8.36 (s, 1H), 8.03 (d, J=9.5 Hz, 1H), 7.93 (d, J=8.7 Hz, 1H), 7.35 (d, J=9.6 Hz, 2H), 4.16 (s, 1H), 3.07 (s, 1H), 2.85 (s, 1H), 2.36 (d, J=10.7 Hz, 2H), 2.18 (d, J=14.1 Hz, 2H), 1.75-1.51 (m, 4H), 1.20 (s, 2H), 1.11 (s, 2H); ESI MS m/z 438 [C25H25F2N3O2+H]+; HPLC 98.5% (AUC), tR=8.70 min.