Trifluoroacetic acid → HCID 178511648, compound

HRID 2271720Notes

Reaction equation

HRID 2271720 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][C:14]([C:20]([CH:22]2[CH2:24][CH2:23]2)=[O:21])=[C:13]3[NH:25][C@H:26]2[CH2:31][CH2:30][C@H:29]([NH:32]C(=O)OC(C)(C)C)[CH2:28][CH2:27]2)[CH:5]=[C:6]([F:9])[C:7]=1[OH:8].C(O)(C(F)(F)F)=O>>[NH2:32][C@H:29]1[CH2:30][CH2:31][C@H:26]([NH:25][C:13]2[C:12]3[C:17](=[CH:18][CH:19]=[C:10]([C:4]4[CH:5]=[C:6]([F:9])[C:7]([OH:8])=[C:2]([Cl:1])[CH:3]=4)[CH:11]=3)[N:16]=[CH:15][C:14]=2[C:20]([CH:22]2[CH2:23][CH2:24]2)=[O:21])[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178454015HCID 178454015, compound

Product 1

HCID 178511648HCID 178511648, compoundYield 88.7%

Procedure

Following general procedure A-2, tert-butyl trans-4-[6-(3-chloro-5-fluoro-4-hydroxyphenyl)-3-(cyclopropanecarbonyl)quinolin-4-ylamino]cyclohexylcarbamate (20 mg, 0.036 mmol) was reacted with TFA (2 mL) to afford the desired product (14.5 mg, 32%) as a yellow solid: 1H NMR (500 MHz, CD3OD) δ 9.13 (s, 1H), 8.35 (d, J=1.8 Hz, 1H), 8.02 (dd, J=8.7, 1.9 Hz, 1H), 7.93 (d, J=8.7 Hz, 1H), 7.56-7.53 (m, 1H), 7.46 (dd, J=11.6, 2.2 Hz, 1H), 4.17-4.11 (m, 1H), 3.28-3.19 (m, 1H), 2.88-2.81 (m, 1H), 2.36 (d, J=12.8 Hz, 2H), 2.18 (d, J=12.2 Hz, 2H), 1.68 (q, J=10.6 Hz, 2H), 1.61-1.50 (m, 2H), 1.23-1.17 (m, 2H), 1.14-1.08 (m, 2H); ESI MS m/z 454 [C25H25ClFN3O2+H]+; HPLC 99.0% (AUC), tR=10.52 min.

Sources & evidence

ORD record
ord-628ace5aa3e34b0eaea3b785d1744513
Source dataset
uspto-grants-2015_09
Patent number
US09120749B2

Reaction notes

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